Expression of anti beta 2 glycoprotein I antibody in patients with systemic lupus erythematosus and the relationship with laboratory indexes

Abstract

Objective To explore the expression of anti beta 2 glycoprotein I (β2GPI) antibody in patients with systemic lupus erythematosus(SLE) and the relationship with laboratory indexes. Methods All of 119 patients with SLE treated in Department of Rheumatology and Immunology in the First Affiliated Hospital of China Medical University from January 2018 to August 2018 were recruited as the SLE group.All of 43 patients with rheumatoid arthritis(RA) were recruited as control group.Anti-β2GPI antibody in serum was detected.The differences of positive rate and expression level of anti-β2GPI antibody in the patients of the two groups were compared.The relationship between anti-β2GPI antibody and other laboratory indexes of patients with SLE was analyzed. Results There was no statistical difference in positive rate of anti-β2GPI antibody between two groups(P>0.05), but the expression level of this antibody in SLE patients was higher than that in control patients[(10.77±13.80)U/mL vs(7.10±5.37)U/mL, P<0.05]. Among SLE patients with positive anti-β2GPI antibody, more patients showed decreased complement C3, increased level of immunoglobulin G and positive anti-nucleosome antibody compared to patients with negative anti-β2GPI antibody(29/39 vs. 44/80, 21/39 vs. 27/80, 22/39 vs. 21/80, all P values <0.05). Conclusion Elevated anti-β2GPI antibody in serum can be found in part of patients with SLE.The positive anti-β2GPI antibody is related to laboratory indexes such as decreased complement C3, increased immunoglobulin G and positive anti-nucleosome antibody. Key words: Systemic lupus erythematosus; Serological testing; Anti beta 2 glycoprotein I antibody