Expression of angiopoietin-related growth factor in obese patients and its significance

Abstract

Objective To investigate the expression of angiopoietin-related growth factor(AGF) in obese patients and its relationship with body mass index(BMI),waist circumference(WC),waist-hip ratio(WHR),blood glucose(FBG),plasma insulin(FINS) levels,and HOMA-insulin resistance index(HOMA-IR).Methods Plasma AGF levels were assayed by ELISA in 40 patients with obesity and 40 normal controls.The relationship of AGF level with BMI,WC,WHR,HbA1c,blood lipids,FBG,FINS,and HOMA-IR was also analyzed.Results AGF levels in patients with obesity were significantly increased compared with that in the control group([177.55 ± 74.09] ng/ml vs [122.37 ± 66.91] ng/ml,P 0.05).We also found that AGF level was positively correlated with Triglyceride(TG),FINS and HOMA-IR(r = 0.325,P 0.05;r = 0.451,P 0.01;r = 0.483,P 0.01);and was negatively correlated with high-density lipoprotein cholesterol(HDL,r =-0.529,P 0.01).Multiple regression analysis showed that HDL,BMI and FINS were the factors influencing AGF levels.Binomial Logistic regression analysis indicated that AGF level was positively correlated with obesity after adjusting sex,age,total cholesterol(TC),TG,HDL and low-density lipoprotein cholesterol(LDL)(OR 1).Conclusion The change of AGF level is associated with the metabolism disorder in obese patients,and it may also contribute to the pathogenesis of obesity.