Abstract
Mammalian cell lines which synthesize and secrete hepatitis B surface antigen (HBsAg) at levels of up to 15 μg/106 cells/day have been obtained by introducing hepatitis B virus eoding sequences into hamster cells together with dihydrofolate reductase cDNA and selecting methotrexate resistant clones. The immunogenic potential of the HBsAg particles tested in guinea pigs is identical to those from human serum. The particles carry, like Dane particles, a receptor for polymerized human serum albumin and may constitute a particularly efficient vaccine.
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