Expression of adenylate kinase 4 in prostate cancer and its clinical significance

Abstract

Objective To investigate the expression of adenylate kinase 4 (AK4) in prostate cancer and its clinical significance. Methods The clinical data of 85 patients with prostate cancer who have underwent radical surgery were retrospectively analyzed. The expression of AK4 in prostate cancer tissues and corresponding paracancerous tissues was detected by immunohistochemistry to analyze the relationship with clinicopathological features. Results The positive rates of AK4 in prostate cancer and paracancerous tissues were 85.9% and 38.8% respectively, and the difference was statistically significant (P<0.05). The abnormal expression of AK4 was correlated with recurrence and distant metastasis (all P<0.05). The survival time of AK4-overexpressing patients with prostate cancer was significantly lower than that of AK4 low-expression patients, and the difference was statistically significant (P<0.05). Conclusions The expression of AK4 in prostate cancer tissues is up-regulated, which is related to the distant metastasis of carcinoma and vascular tumor thrombus, which suggests that the expression of AK4 may indicate the poor prognosis of patients with prostate cancer. Key words: Prostate cancer; Immunohistochemistry; Adenylate kinase 4; Prognosis