Expression of adenomatous polyposis coli in primary gastric lymphoma tissue and its relationship with helicobacter pylori

Abstract

Objective To investigate the expression and significance of adenomatous polyposis coli (APC) protein in primary gastric lymphoma (PGL) tissue, and explore its relationship with H. pylori. Methods The clinical and pathological data of 45 patients with PGL admitted between June 2006 and December 2011 in Xiangya Hospital and Shaoyang Chinese Medicine Hospital were collected. Expression of APC protein was detected with immunohistochemical staining (SP) in 45 cases (32 cases were male and 13 cases female, 33 cases were less than 60 years old, 12 cases were equal to or more than 60 years old, 35 cases were Hp positive, and 10 cases Hp negative), and 30 samples of normal gastric mucosa tissues. Results The positive expression rate of APC protein was 37.78% (17/45) in PGLs, and 90.0% (27/30) in normal gastric mucosa tissues. There was significant difference between PGLs and normal gastric mucosa tissues (P<0.05). The positive expression rate of APC protein in PGL was 25.71% (9/35) in those with Hp infection, and 80.00% (8/10) without Hp infection. There was significant correlation between the expression of APC and Hp infection (P<0.05). Conclusions The APC protein was lowly expressed in PGL. Because of the significant correlation between low expression of APC protein and Hp infection, Hp infection might be an important factor that impacts on the expression of APC protein. Key words: Lymphoma/PA; Helicobacter infections; Adenomatous polyposis coli/ME; Adenomatous polyposis coli protein/ME