Abstract
Abstract Mast cells are innate immune cells best characterized for their role in allergy. In response to cross-linking of the high-affinity IgE receptor, FcϵRI, mast cells release mediators such as histamine, leukotrienes, IL-6, and TNF-α. Additionally, mast cells are widely noted for their secreted proteases like chymases and cathepsins. We have decided to investigate the role that the protease A Disintegrin and Metalloproteinase 10 (ADAM10) plays on murine mast cells. To date, we have discovered mast cells express ADAM10 in vitro and in vivo, and that Treg cytokines TGF-β1 and IL-10 down regulate mast cell ADAM10. IL-10 effects depend on STAT3. ADAM10 deletion results in abrogated mast cell migration through Collagen IV to stem cell factor, but not to antigen. Also, ADAM10 deletion decreases IL-6 release post cross-linking, but does not alter other commonly released cytokines such as TNF-α, IL-13, and MIP-1α. Because of these findings, we hypothesize that ADAM10 plays a pro-inflammatory role in mast cell migration and also in allergic disease.
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