Abstract
The expression of VH4 gene family during immunoglobulin heavy chain synthesis has been detected in autoimmune diseases. In particular, the rat monoclonal antibody 9G4 detects VH4-34-encoded immunoglobulins and B cells expressing these antibodies as surface receptor (autoreactive 9G4+ B cells).
Highlights
The expression of VH4 gene family during immunoglobulin heavy chain synthesis has been detected in autoimmune diseases
Patients and methods Serum from 27 patients with established rheumatoid arthritis (RA) and 46 polyarthritis patients (
We describe for the first time the expression of VH4-34 heavy chain gene by autoantibodies to citrullinated peptides early after RA onset
Summary
The expression of VH4 gene family during immunoglobulin heavy chain synthesis has been detected in autoimmune diseases. The rat monoclonal antibody 9G4 detects VH4-34-encoded immunoglobulins and B cells expressing these antibodies as surface receptor (autoreactive 9G4+ B cells). Aim To determine whether autoantibodies commonly associated with rheumatoid arthritis (RA) express 9G4 idiotope (9G4-Id)
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