Abstract
Cholesteatoma consists of a keratinising squamous epithelium in the middle ear cavity. The human 4F2 antigen appears at the end of the phase G0 and at the beginning of the phase G1, remaining detectable throughout mitosis. This antigen is therefore considered to be an activation marker. In this study the presence and distribution of 4F2 in the cholesteatoma epithelium was investigated using monoclonal antibodies and the alkaline-phosphatase-anti-alkaline-phosphatase method. Normal skin showed positive immunostaining exclusively in the basal keratinocytes. In contrast, all cholesteatomas showed a suprabasal expression of the 4F2 antigen. The results confirm the hyperproliferative character of cholesteatoma epithelium.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
