Expression of 2-nd Receptor of Tumor Necrosis Factor Cytokine (TNFR-II) in Canine Mammary Neoplasms

Abstract

Actual study proposes an actual and controversial theme in oncology, such as expression and distribution of TNF cytokine 2-nd receptor in canine mammary cancer, and its involvement in cancer progression and prognosis. TNFR-II was evaluated by LSAB immunohistochemistry technique using anti-TNFR-II marker. Tumor malignancy was appreciated using histology grading (I to III), mitotic index, nuclear grade, tumor size, and histology type. In the study were elected benign and malign canine mammary tumors. Distribution and localization of TNFR-II was restricted in both inflammatory cells from the sustaining stroma of studied tumors (macrophage, lymphocyte), and in cancerous epithelial or myoepithelial cells. Obtained dates demonstrate a direct relation between histologic grade and TNFR-II expression; TNFR-II had a lower expression in benign and differentiated grade I canine mammary tumors (cancerous epithelial and myoepithelial cells), and a higher expression in poorly differentiated ones (grade II cancers).