Expression levels of serum osteopontin, adenosine kinase 1 and Dikkopf 1 in patients with lung cancer and their clinical significances

Abstract

Objective To observe the expression levels of serum osteopontin (OPN), adenosine kinase 1 (TK1) and secretory protein Dikkopf 1 (DKK1) in patients with lung cancer and their clinical significances. Methods Lung cancer patients treated in the First Affiliated Hospital of Xi'an Medical University from February 2017 to April 2018 were selected as the lung cancer group (60 cases), and 60 healthy adults who received physical examination in the same period were selected as the control group. The differences of serum OPN, TK1 and DKK1 levels between the lung cancer group and the control group and lung cancer patients with different characteristics were compared. Measurement data were compared by using t test. Results The levels of serum OPN, TK1 and DKK1 in lung cancer patients were (38.56±3.18) μg/L, (4.69±1.03) pmol/L and (3.76±0.89) ng/ml, respectively, which were higher than those in the control group [(15.98±2.06) μg/L, (1.01±0.22)pmol/L, (1.21±0.24) ng/ml; t=-46.162, -27.064, -21.428, all P 0.05). The levels of serum OPN, TK 1 and DKK1 in stage Ⅲ-Ⅳ lung cancer patients were (57.18 ±3.12) μg/L, (6.26±1.28) pmol/L and (4.98±1.03) ng/ml, respectively, which were higher than those in stage Ⅰ-Ⅱ lung cancer patients [(30.35±2.96) μg/L, (3.49±0.67) pmol/L, (3.01±0.96) ng/ml; t= -34.156, -10.690, -7.665, all P < 0.01]. The levels of serum OPN, TK 1 and DKK1 in non-small cell lung cancer (NSCLC) patients were (55.13±5.02) μg/L, (5.96±1.11) pmol/L and (5.02±1.32) ng/ml, respectively, which were higher than those in small cell lung cancer (SCLC) patients [(29.68±3.16) μg/L, (3.13±0.98) pmol/L, (2.86±0.56) ng/ml; t = -22.353, -10.213, -7.688, all P < 0.01]. Conclusion The levels of serum OPN, TK1 and DKK1 in patients with lung cancer are higher, which are related to the type and stage of lung cancer. Key words: Lung neoplasms; Small cell lung carcinoma; Carcinoma, non-small-cell lung; Osteopontin; Adenosine kinase; Dikkopf 1