Abstract
BackgroundPyroptosis plays a dual role in the development of cancer and malignancy; as such, it may potentially be a new target for cancer treatment. However, the inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and related proteins associated with pyroptosis in cancer remain controversial.AimThe goal of this study was to determine whether the expression levels of caspase‐3 and GSDME affect the clinical stage, pathological grade, or survival prognosis of patients with lung cancer.MethodsWe examined the protein levels of GSDME, caspase‐3, caspase‐8, and caspase‐9 in lung tissue samples from 100 patients with lung cancer by using immunohistochemistry.ResultsWe found that GSDME, caspase‐3, and caspase‐8 were more highly expressed in tumor tissues than in adjacent normal tissues. Moreover, we found that GSDME could serve as a prognostic factor as there was a positive correlation between its expression level and the postoperative survival rate of patients with lung cancer.ConclusionsGSDME may be an independent factor affecting the prognosis of patients with lung cancer. However, the role of GSDME and its related proteins in cancer requires further research.
Highlights
Pyroptosis plays a dual role in the development of cancer and malignancy, and as such, may potentially be a new target for cancer treatment
This study aimed to explore whether the expression levels of caspase-3 and gasdermin E (GSDME) affect the clinical stage, pathological grade, and survival prognosis of patients with lung cancer
We found that GSDME, caspase-3, and caspase-8 were more highly expressed in the tumor tissues than in the adjacent normal tissues
Summary
Pyroptosis plays a dual role in the development of cancer and malignancy, and as such, may potentially be a new target for cancer treatment. The inflammatory response to pyroptosis may have adverse effects on the body. The roles of gasdermin E (GSDME), caspases, and related proteins associated with pyroptosis in cancer remain controversial. This study aimed to explore whether the expression levels of caspase-3 and GSDME affect the clinical stage, pathological grade, and survival prognosis of patients with lung cancer
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