Abstract
Objective To investigate the expression levels of YKL-40 and CA125 in the serum and peritoneal fluid of patients with endometriosis (EMS), and discuss the relationship between YKL-40, and CA125. Methods From March 2012 to March 2014, a total of 50 cases with EMS were included into this study (EMS group). At the same time, another 40 cases with benign uterus tumor were included into control group. There were no significant differences between two groups in the aspects of age, body mass index, the constituent ratio of algomenorrhea, the constituent ratio of infertility, and duration of infertility (P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Xuzhou Central Hospital, Affiliated Reproductive Medical Central of Southeast University. Informed consent was obtained from each patient. Serum and peritoneal fluid levels of YKL-40 in both two groups were detected by enzyme-linked immunosorbent assay (ELISA), and serum and peritoneal fluid levels of CA125 were detected by electrochemiluminescence method. The relationship between CA125, YKL-40 and EMS were analyzed by Spearman correlation analysis. Results ①The serum and peritoneal fluid levels of CA125 and YKL-40 in EMS group were both significantly higher than those of control group, which with significant differences (P<0.05). ②The serum and peritoneal fluid levels of CA125 and YKL-40 in stage Ⅲ-Ⅳ of EMS group were significantly higher than those of stage Ⅰ-Ⅱ, which with significant differences (P<0.05). The serum levels of YKL-40 in stage Ⅰ-Ⅱ, stage Ⅲ-Ⅳwere significantly higher than those of control group, and the peritoneal fluid levels of YKL-40, CA125 in stage Ⅰ-Ⅱ, stage Ⅲ-Ⅳwere significantly higher than those of control group, respectively, which both with significant differences (P<0.05). ③Serum and peritoneal fluid levels of YKL-40 showed positive correlation with CA125 (r=0.504, 0.401; P<0.01) by Spearman correlation analysis (P<0.05). Conclusions The serum and peritoneal fluid levels of YKL-40 might be an useful diagnosing and prompting clinical staging biomarker of EMS. Key words: Endometriosis; YKL-40; Clinical staging
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