Expression Level of Valosin Containing Protein is Associated with Prognosis of Primary Orbital MALT Lymphoma

Wen-Wen Zhu,Guang Yang,Yan Hei,Jie Dong,Li Kang,Ya-Ping Gao,Li-Hua Xiao,Yu Liu

doi:10.7314/apjcp.2013.14.11.6439

Abstract

To investigate whether the expression level of valosin-containing protein (VCP) is correlated with the prognosis of primary orbital mucosa-associated lymphoid tissue (MALT) lymphoma. VCP expression in 58 samples from primary orbital MALT lymphoma patients was determined by immunohistochemisty using monoclonal antibodies. Correlations between VCP expression level and prognosis were clarified by statistical analysis. It was found that the percentage of VCP positive cells in samples of primary orbital MALT lymphoma ranged from 32% to 95%. The samples were divided into two groups (level 1 and level 2) according to the median value (45%) of the percentage of VCP positive cells. It was found that the expression level of VCP was significantly correlated with recurrence (P=0.003) and tumor size (P=0.008). At the same time, the 5-year disease-free and overall survival rate of patients of level 1 was significantly better than that of level 2 (P=0.001; P=0.032). There was no observed correlation between the expression level of VCP and other clinical features. VCP could be a useful marker for predicting the prognosis of primary orbital MALT lymphoma.

Highlights

Non-Hodgkin’s lymphoma (NHL) constitutes one half of malignancies arising in the orbit and the ocular adnexae
It was found that the percentage of valosin-containing protein (VCP) positive cells in samples of primary orbital mucosa-associated lymphoid tissue (MALT) lymphoma ranged from 32% to 95%
It has been demonstrated that the expression of VCP varies in different patients with primary orbital MALT lymphoma

Summary

Introduction

Non-Hodgkin’s lymphoma (NHL) constitutes one half of malignancies arising in the orbit and the ocular adnexae. It is remarkable that as a part of systemic disease, primary orbital MALT lymphoma has the possibility of recurrence in the distant organs after initial therapy (Raderer et al, 2005; Sjö et al, 2009; Goda et al., 2011; Graue et al, 2013). Several reports have revealed that CD5 (Wenzel et al, 2001), CD43 (Nola et al, 2004), and Bcl (Franco et al, 2006) are involved in the progression of ocular adnexal lymphoma, but until now, there is no specific marker for recurrence of the primary orbital MALT lymphoma. Several studies have revealed VCP is associated with the prognosis of gastric cancer (Yamamoto et al, 2003), colorectal cancer (Yamamoto et al, 2004), and liver cancer (Yamamoto et al, 2003)

Serum albumin

Patients outcome

VCP expression

Findings

Discussion