Abstract
Abstract Background Gestational diabetes mellitus (GDM), which has been identified for the first time during pregnancy and is defined as glucose intolerance of varying degrees, is one of the prediabetes states that are at risk for developing type 2 diabetes. MicroRNAs (miRNAs) are associated with pregnancy complications and are even necessary for the regulation of pancreatic development and glucose-induced insulin secretion. This study aims to investigate miRNAs expressed in maternal plasma to detect the availability as a biomarker in the diagnosis of GDM. Methods In this study, 30 pregnant women with GDM diagnosed according to GDM American Diabetes Association criteria and 30 healthy pregnant women were included and miRNA expression levels were investigated. Circulating 39 miRNAs were analyzed by qRT-PCR using 96.96 Dynamic Array IFCs. Results The findings showed that the expression level of miR-7-5p significantly upregulated when compared with healthy pregnant women with gestational diabetes (fold change:2.3, p<0.05). Conclusions There is controversy about what is the most appropriate test for GDM screening. Therefore, supported by further studies, miR-7-5p can be used for the diagnosis of GDM.
Highlights
Gestational diabetes mellitus (GDM) is glucose intolerance at various grades that first occurred in pregnancy
The findings showed that there was no significant difference in age between the control group and pregnant women with GDM
We searched articles indexed in PubMed (MEDLINE) database using Title/Abstract words (‘‘microRNA’’ or ‘‘miRNA’’ and ‘‘diabetes”) and mirbase
Summary
Gestational diabetes mellitus (GDM) is glucose intolerance at various grades that first occurred in pregnancy. Insulin resistance may be tolerated in most pregnant women, while a small part does not have adequate adaptation and GDM occurs. This adaptation is attempted to provide increased insulin synthesis in the islets of the pancreas, increased insulin secretion due to glucose, increase in pancreatic beta-cell mass, glucose metabolism and increased cAMP metabolism [1,2,3,4]. Gestational diabetes mellitus (GDM), which has been identified for the first time during pregnancy and is defined as glucose intolerance of varying degrees, is one of the prediabetes states that are at risk for developing type 2 diabetes. Supported by further studies, miR-7-5p can be used for the diagnosis of GDM
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