Expression Level of IL-17 in Peripheral Blood of Patients with Late Pregnancy and Diagnosis of Maternal-Fetal Tolerance Based on Brain MRI Image Segmentation Algorithm.

Zenying Yu,Shengyan Zhou,Zhen Tan,Guangmin Lu

doi:10.12669/pjms.37.6-wit.4828

Abstract

Objectives:To study the expression of IL-17 in peripheral blood and its effect on maternal-fetal tolerance in patients with eclampsia in late pregnancy using MRI image segmentation algorithm.Methods:Thirty-nine patients with severe preeclampsia and eclampsia with brain symptoms were examined by cranial MRI. Pregnant women with 32 weeks of pregnancy were selected to detect the percentage of Th17 and Treg cells in CD4 + T lymphocytes and the expression of cytokines IL-17 and IL-10 in peripheral blood.Results:MRI examination was normal in 26 cases, 9 cases showed reversible posterior encephalopathy syndrome, three cases were cerebral hemorrhage, and one case was intracranial cavernous sinus thrombosis. two. Compared with the mild preeclampsia group, the relative number of Thl7 cells increased and that of Treg cells decreased in the severe preeclampsia group (P>0.05).Conclusion:The major types of cerebrovascular diseases (CVD) in severe preeclampsia and eclampsia were reversible posterior encephalopathy syndrome and cerebral hemorrhage. It was speculated that the damage to the blood-brain barrier may play an important role in the pathogenesis. The balance of the number of Th17 cells/the number of Treg cells was more inclined to the Th17 cell-mediated pro-inflammatory state, Treg cell-mediated immune tolerance decreases, and it becomes more obvious with the worsening of the disease.

Highlights

Preeclampsia (PE) is a common pregnancy complication, usually involving multiple organ functions and a series of maternal and infant complications
The serum uric acid level in the control group was lower versus the research group, showing notable differences (P
There was no statistical comparison of red blood cell volume, platelet count, blood calcium, blood urea nitrogen, alkaline phosphatase, hemoglobin, plasma albumin, blood creatinine, aspartate aminotransferase, and alanine aminotransferase in the two groups, P>0.05

Summary

Introduction

Preeclampsia (PE) is a common pregnancy complication, usually involving multiple organ functions and a series of maternal and infant complications. It is found that immune factors are closely related to the occurrence and development of PE.[1] Treg cells can induce the formation of immune tolerance, make pregnancy progress smoothly, and have unique immunoregulatory functions. Thl[7] can mediate inflammatory responses and secrete interleukin 17 (IL-17), interleukin 22 (IL-22) and other cytokines. Thl[7] and Treg cells may be involved in embryo immune rejection and inflammation of pathological pregnancy such as PE.[2]. Pak J Med Sci September 2021 (Speical Issue Online) Vol 37 No 6 www.pjms.org.pk 1553

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