Expression level and its clinical significance of human epidermal growth factor receptor 2, estrogen receptor, progesterone receptor, P53 and Ki-67 in breast cancer tissues of elderly patients

Abstract

Objectives To investigate the expression level and its clinical significance of human epidermal growth factor receptor 2(C-erbB-2), estrogen receptor(ER), progesterone receptor(PR), Ki67 and P53 in breast cancer tissues of elderly patients. Methods The expressions of C-erbB-2, ER, PR, Ki67 and P53 in 103 specimens of breast cancer tissues were assessed by immunohistochemistry(S-P), and their relationships with clinicopathological factors including tumor size, lymph node metastasis status and clinical stages were statistically analyzed. Results The positive rate of C-erbB-2, ER, PR, Ki67 and P53 in 103 cases was 17.5%(18/103), 64.1%(66/103), 54.4%(56/103), 70.9%(73/103)and 66.0%(68/103), respectively.The positive expression rates of C-erbB-2 and P53 were correlated with clinical stages and lymph node metastasis status(P 0.05). The positive expression rates of C-erbB-2, P53, ER and PR were irrelevant to tumor size(P>0.05). Conclusions The expression of C-erbB-2, ER, PR, Ki67 and P53 could be biological markers for estimating the occurrence and progression of elderly breast cancer.Detection of C-erbB-2, ER, PR, Ki67 and P53 may help judge the clinical stages and lymph node metastasis status in elderly patients with breast cancer. Key words: Breast neoplasms; Tumor markers, biological