Abstract
Objective To assess the feasibility of urinary PEBP1 as a potential biomarker of congenital obstructive hydronephrosis. Methods A total of 60 children with hydronephrosis(severe and mild hydronephrosis groups) and 30 healthy children were enrolled to define the expression of PEBP1 in bladder urine samples by ELISA.Correlation analysis and ROC analysis were used to define the expression of PEBP1 and diagnostic profile in identifying children with impaired split renal function. Results The PEBP1 levels decreased significantly and positively correlated with split renal function in study group before surgery(r=0.818, P<0.05). One month after surgery, it increased significantly.An area under the curve for PEBP1 protein of 0.89 with a best cutoff value of 0.521 ng/mg cr and the impaired split renal function decreased to 30% or less(sensitivity 80%, specificity 90%) was found. Conclusion Decreased PEBP1 may be a potential biomarker for the diagnosis of congenital hydronephrosis in children, and it can also be used to assess the severity of the disease and the therapeutic effect. Key words: PEBP1; Hydronephrosis; Urine; Biomarker
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