Abstract
Objective To investigate the expression and clinical significance of thyroid transcription factor-1 (TTF-1) and chromogranin A (CgA) in small cell lung cancer (SCLC). Methods The expressions of TTF-1 and CgA protein in 68 cases of SCLC tissues and 20 cases of normal lung tissues were examined by immunohistochemistry method, and their correlations with clinical features of SCLC were analyzed. Results The positive rates of TTF-1 and CgA protein in SCLC were 88.2% (60/68) and 70.6% (48/68), respec-tively, and they were higher than those in normal lung tissue [10.0%(2/20) and 5.0%(1/20); χ2=45.442, P=0.000; χ2=26.941, P=0.000]. The expression of TTF-1 protein was not related to the patients′ age, sex and tumor size, while closely related to smoking index (χ2=4.131, P=0.042), lymph node metastasis (χ2=5.488, P=0.019) and clinical stage (χ2=6.011, P=0.014). The expression of CgA protein was not related to the patients′ age, sex, tumor size and smoking index, while closely related to lymph node metastasis (χ2=9.895, P=0.002) and clinical stage (χ2=4.145, P=0.042). Conclusion TTF-1 and CgA protein are highly expressed in SCLC, especially in the patients with lymph node metastasis and extensive disease. Key words: Carcinoma, small cell; Chromogranin A; Immunohistochemistry; Thyroid transcription factor-1
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