Expression and Significance of Toll-Like Receptor 1 and Toll-Like Receptor 3 in Renal Tissues of Children with Primary Nephrotic Syndrome

Abstract

To explore the expression and clinical significance of toll-like receptor 1 and toll-like receptor 3 in renal tissues of children with primary nephrotic syndrome. A total of 120 children with primary nephrotic syndrome kidney tissues who underwent renal biopsy were selected as the observation group, which can be divided into minimal change disease type (40 cases), membranous nephropathy type (20 cases), mesangial proliferative glomerulonephritis type (30 cases) and focal segmental glomerulosclerosis type (30 cases). In addition, the normal kidney tissues of 20 children with Wilms tumor admitted to the same period were selected as the control group and immunohistochemistry was used. The method was used to detect the expression levels of toll-like receptor 1 and toll-like receptor 3 in the kidney tissues of the two groups. Compared with the control group, the different pathological types in the observation group had higher expression levels of toll-like receptor 1 in renal tubular tissues. The expression levels of toll-like receptor 1 in minimal change disease type renal tubular tissues in different pathological types of tissues were significantly higher than those in other groups, followed by membranous nephropathy. In mesangial proliferative glomerulonephritis type and focal segmental glomerulosclerosis type, the difference was statistically significant (all p<0.05). Compared with the control group, the different pathological type groups in the observation group had higher expression levels of toll-like receptor 3 in renal tubular tissues. The expression levels of toll-like receptor 3 in mesangial proliferative glomerulonephritis type renal tubular tissues in different pathological types of tissues were significantly higher than those in other groups, followed by membranous nephropathy type, minimal change disease type and focal segmental glomerulosclerosis type, the difference was statistically significant (all p<0.05). Toll-like receptor 1 and toll-like receptor 3 have high expression levels in the renal tissues of children with primary nephrotic syndrome and their expression levels have certain differences in different pathological types.