Expression and significance of serum milk fat globule epidermal growth factor 8, carbohydrate antigen 125, carcinoembryonic antigen in patients with breast cancer

Abstract

Objective To explore the expression and clinical significance of serum milk fat globule epidermal growth factor 8(MFG-E8), carbohydrate antigen 125(CA125), carcinoembryonic antigen(CEA) in patients with breast cancer. Methods The levels of serum MFG-E8, CA125, CEA were detected in 108 cases patients with breast cancer(breast cancer group) and 108 cases patient with benign breast tumors(benign breast tumor group). The level of each indicators between malignant and non-malignant, metastasis and non-metastasis were compared, and diagnosis value of breast cancer by individual and combined detection were analyzed. Results Compared with benign breast tumors group((207.2±47.1) ng/L, (8.64±2.86) U/ml, (1.38±0.37) μg/L), the levels of serum MFG-E8, CA125 and CEA((5 182.1±564.5) ng/L, (34.22±7.20) U/ml, (4.41±1.22) μg/L) were increased significantly in breast cancer group(t=91.27, 34.31, 24.70; P 0.05). The sensitivity of combined detection of three indicators were 82.4%, significantly higher than any of MFG-E8, CA125, CEA alone(P<0.05), the diagnose accuracy rate was 85.2%, significantly higher than CA125, CEA alone(P<0.05). Conclusion The levels of serum MFG-E8, CA125, CEA in patients with breast cancer are over-expressed, combined detection has certain guiding significance for diagnosis and choice of therapeutic regimen. Key words: Breast cancer; Milk fat globule epidermal growth factor 8; Carbohydrate antigen 125; Carcinoembryonic antigen; Diagnosis