Expression and significance of PTEN and Claudin-3 in prostate cancer.

Abstract

Expression and significance of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and Claudin-3 in the blood of patients with prostate cancer [prostate cancer (PCa)] were investigated. Retrospective analysis of 84 cases of PCa patients confirmed by pathological diagnosis were studied, as the experiment group. Moreover, the physical examination data of 84 healthy volunteers examined in the Affiliated Hospital of Beihua University were the control group. The expression levels of blood in the PTEN and Claudin-3 of both the experiment group and the control group were determined by enzyme-linked immunosorbent assay. According to the blood expression in PTEN and Claudin-3 between both the experiment group and the control group, the test value of the ROC curve in PTEN and Claudin-3 were detected by both single detection and joint detection. The expression levels of PTEN in the experiment group were significantly lower than the control group (P<0.05). The expression levels of Claudin-3 were higher in the experiment group than the control group (P<0.01). The expression levels of PTEN and Claudin-3 in the experiment group were significantly associated with the distant metastasis of cancer cells, preoperative prostate-specific antigen levels, tumor diameter and pathological stages (P<0.01). The expression levels of PTEN in the pathological stage of T1-T2 group was lower than that of the T3-T4 group (P<0.01). The expression levels of PTEN and Claudin-3 are closely related to the distant metastasis of cancer cells, preoperative prostate-specific antigen level, tumor diameter and pathological stage. Combined detection of both PTEN and Claudin-3 can improve the specificity levels of PCa for diagnosis and has an important diagnostic value for PCa. It can be used as a biological indicator for PCa diagnosis, disease severity analysis and efficacy evaluation.