Abstract
Objective To investigate the expression and significance of pituitary homeodomain protein transcription factor 1 (PITX1) and immunoglobulin heavy chain binding protein (BiP/GRP78) in human cutaneous malignant melanoma (CMM) tissues. Methods Immunohistochemistry was used to detect the expression of PITX1 and BiP/GRP78 protein in 40 cases of CMM, 23 cases of skin junction and 20 cases of normal skin tissue, and to explore their relationships with CMM occurrence and infiltration. Results The positive expression rates of PITX1 and BiP/GRP78 protein in the three tissues were statistically significant (χ2=8.940 and 10.023, P 0.05), and the correlation was not statistically significant. Conclusion PITX1 and BiP/GRP78 play an important role in the development of CMM, which may provide a new way for CMM clinical diagnosis and prognosis evaluation. Key words: Cutaneous malignant melanoma; Pituitary homeodomain protein transcription factor 1; Immunoglobulin heavy chain binding protein
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