Abstract
Objective To investigate the expressions and significance of phosphorylation extracellular signal-regulated kinase (PERK) and c-fos in condyloma acuminatum (CA) tissue. Methods The expressions of PERK and c-fos were detected by immunohistochemical staining in 30 cases of CA tissue and 20 cases of normal foreskin tissue. Results The expression rate of PERK and c-fos in CA tissues was 66.67%(20/30) and 56.67%(17/30), respectively, while it was 5.00%(1/20), 10.00%(2/20), respectively in normal foreskin tissue. The expression intensity of PERK and c-fos in CA tissues was positive to strong positive and it was negative to positive in normal tissues. There were significant differences in expression rate and intensity of PERK and c-fos between CA tissues and normal foreskin tissues (P<0.05). PERK and c-fos expression were positively correlated in CA tissues (r=0.523, P<0.05). Conclusions There is an over-expression of PERK and c-fos in CA tissues, which may be involved in the development and progression of CA. Key words: Phosphorylation extracellular signal-regulated kinase; c-fos; Condyloma acuminatum
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