Abstract
Objective To detect the expression of macrophage migration inhibitory factor(MIF) in the myocardium of diabetic rats, and to investigate its role in the pathogenesis of diabetic cardiomyopathy. Methods Thirty male SD rats were randomly divided into three groups: normal control group (CON), diabetes for 1 month group (DM1) and diabetes for 2 months group (DM2). The diabetic rat model was induced by intraperitoneal injection of streptozotocin. The expression of myocardial MIF was detected by immunohistochemistry. Results Compared with the normal control group, the expression of MIF in myocardium increased significantly in the diabetic groups, and the DM2 group was significantly higher than the DM1 group (P<0.01). Conclusions As the disease progresses, the expression of MIF in myocardium of diabetic rats gradually increased, so MIF may participate in the progression of diabetic cardiomyopathy. Key words: Diabetic cardiomyopathy; Macrophage migration inhibitory factor; Rats
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