Expression and significance of lysine-specific histone demethylase 2B in gastric cancer

Abstract

Objective To study the expression and significance of lysine-specific histone demethylase 2B (KDM2B) protein in gastric cancer and its correlation with clinicopathologic features and prognosis for gastric cancer. Methods The expression of KDM2B protein was detected by the immunohistochemical staining. The relationship between the expression of KDM2B and clinicopathologic characteristics in gastric cancer was analyzed by χ2 test and survival analyses were done by the Kaplan-Meier method and Cox regression, and the differences between the curves were tested with the two-tailed log-rank test. Results The positive rate of KDM2B protein was 58.9% in 236 cases of gastric cancer, and 11.4% in the adjacent gastric mucosa (χ2=25.690, P=0.000). The positive rate of KDM2B was correlated with histological classification, lymph node status, TNM stage and human epidermal growth factor receptor-2 (Her-2) expression (χ2=12.922, 6.817, 15.089, 5.143, P=0.002, 0.033, 0.001, 0.023, respectively). The Kaplan-Meier analysis showed KDM2B was associated with poor prognosis [hazard ratio (HR)=2.340, P=0.000]. The 5-year survival rate of KDM2B positive gastric cancer was 22.3%, and the median survival time was 19 months. The 5-year survival rate of KDM2B negative gastric cancer was 49.5%, and the median survival time was 55 months. Furthermore, Cox stepwise hazard analysis revealed KDM2B was an independent prognostic index for gastric cancer. Conclusion KDM2B was an independent prognostic index for gastric cancer. Key words: Gastric cancer; Lysine-specific histone demethylase 2B; Prognosis; Immunohistochemistry