Expression and significance of KLF6 protein in gastritis,intraepithelial neoplasia and gastric cancer

Abstract

Objective To investigate the significance of KLF6 protein in the progress of gastric cancer. Methods The protein expression of KLF6 in the 36 cases of chronic atrophic gastritis,high-grade intraepithelial neoplasia and gastric carcinoma were detected respectively,and the relationship be-tween KLF6 and clinicopathological parameters was analyzed. Results The expression of KLF6 protein was lower in gastric cancer group and intraepithelial neoplasia group than that in gastritis group,and it was lower in gastric carcinoma group than that in intraepithelial neoplasia group（ P 〈 0. 05）. The positive＆amp;nbsp;expression rates of KLF6 protein were different in different degree differentiation of gastric cancer,and there were significant differences in different TNM stages of gastric cancer（P 〈 0. 05）,and the higher TNM stage was,the lower the positive expression rate of KLF6 protein become. And there were no rela-tionship with lymph node metastasis,tumor location,the level of gastric cancer invasion or tumor size （P 〉 0. 05）. Conclusions The abnormal expression of KLF6 is closely related to the occurrence,de-velopment and differentiation of gastric cancer. KLF6 protein expression has certain reference value in the diagnosis and prognosis of gastric cancer. Key words: Chronic atrophic gastritis; Intraepithelial neoplasia; Gastric cancer; KLF6