Expression and Significance of Hepatitis B Virus X Protein and Hepatitis B Virus DNA Levels in Renal Tissue of Patients with Glomerulonephritis and Hepatitis B Virus Infection

Abstract

To investigate the expression and clinical significance of hepatitis B virus X protein and hepatitis B virus deoxyribonucleic acid in hepatitis B virus associated nephritis. 78 patients with hepatitis B virus associated nephritis treated in our hospital from January 2018 to January 2020 were selected as observation group. At the same time, 70 patients with nephritis with positive hepatitis B markers but without hepatitis B surface antigen and/or hepatitis B core antigen deposition in renal tissue were selected as the control group. The clinical data, hepatitis B virus X protein and hepatitis B virus deoxyribonucleic acid were compared between the two groups. There was no significant difference in white blood cells, red blood cells, platelet count test, activated partial thromboplastin time, prothrombin time between the observation group and the control group (p>0.05). The positive rate of hepatitis B virus X protein and the proportion of hepatitis B virus deoxyribonucleic acid >105 IU/ml in the observation group were 61.54 %, 89.74 % and 52.56 % respectively, which were significantly higher than those in the control group (p<0.05). The proportion of ‘Xiaosanyang’ and hepatitis B virus deoxyribonucleic acid <103 IU/ml were 32.05 % and 11.54 % respectively, which were significantly lower than those in the control group (p<0.05). The proportion of hepatitis B virus deoxyribonucleic acid quantification >105 IU/ml in the observation group was 62.50 %, which was significantly higher than that in the non-three-positive patients (p<0.05). The proportion of patients with hepatitis B virus deoxyribonucleic acid quantification >105 IU/ml in the observation group was 76.00 %, which was significantly higher than that in patients with effective treatment (p<0.05). The levels of hepatitis B virus X protein and hepatitis B virus deoxyribonucleic acid in patients with hepatitis B virus-associated nephritis were higher and the level of hepatitis B virus deoxyribonucleic acid was related to Sanyang and therapeutic effect, but hepatitis B virus X protein was not significantly correlated.