Expression and Significance of FABP4 and miRNA-182 in Plasma and Placental Tissues of Patients with Hypertensive Disorders During Pregnancy

Abstract

Objective: To investigate the expression and significance of fatty acid binding protein 4 (FABP4) and microRNA-182 (miRNA-182) in the plasma and placental tissues of patients with hypertensive disorders in pregnancy (HDIP). Methods: 141 mothers admitted to The Affiliated Hospital of Hebei University between January 2019 and December 2022 were selected. The patients were divided into the observation group (61 HDIP patients) and control group (80 healthy pregnant women) based on the criteria for determining hypertensive diseases in pregnancy. The differences in the expression of FABP4 and miRNA-182 between the two groups were compared. Results: The expression levels of FABP4 in plasma and placental tissues of the observation group were significantly higher than those of the control group (P< 0.05). Conversely, the expression levels of miRNA-182 in the plasma and placental tissues of the observation group were significantly lower than those of the control group (P < 0.05). A negative correlation was observed between the plasma level of FABP4 and miRNA-182. However, there was no significant correlation between the expression levels of FABP4 and miRNA-182 in placental tissues. While plasma FABP4 levels exhibited a positive correlation with the severity of HDIP, miRNA-182 expression levels did not significantly correlate with the severity of HDIP. Conclusion: The expression of FABP4 and miRNA-182 in plasma and placental tissues of patients with HDIP differed significantly from that of healthy pregnant women. This observation may provide a new perspective on the pathogenesis of HDIP.