Expression and significance of ERβ,FasL and HSP90 in endometrial polyps

Abstract

Objective To investigate the expression and the relationships of estrogen receptor β(ERβ), Fas ligand (FasL) and heat shock protein 90 (HSP90) in endometrial polyps (EP) in the infertility woman.Methods Proliferative phase of endometrium and EP from infertility woman were divided into two groups.The mRNA expression of ERβ,FasL and HSP90 in each group was detected by RT-PCR.Results The mRNA expression of ERβ, FasL and HSP90 in EP were 0.209±0.094.1.053.±0.201 and 0.625±O.126,respectively,which were lower than that of the control group (0.377±O.122,0.659±O.157 and 0.401±0.083),respectively.The expression of ERβ was lower than that in EP tissue,but it had no significant difference from normal endometrium (P>0.05).The expression of FasL and HSP90 were highel compared with that of the control group.Correlation test shows that FasL and HSP90 had negative correlation with ERβ(r=-0.552,-0.401,P<0.05),and FasL is positively correlaed with HSP90(r=0.631,P<0.05).Conclusions Increased mRNA expression of FasL and HSP90 in EP may be involved in the pathogenesis of EP and may also contribute to the negative correlation of them with the mRNA expression level of ERβ. Key words: Infertility; Endometrial polyps; Estrogen receptor β; Fas ligand; Heat shock protein 90