Abstract
Objective To explore the role of Wnt/β-catenin signal transduction pathway in the aspect of tumorigenesis of brainstem and supratentorial gliomas by detecting the expression of β-catenin.Methods The expression of β-catenin was detected in 6 normal brain tissue,10 grade Ⅱ brainstem gliomas and 10 grade Ⅱ supratentorial gliomas by immunohistochemistry and Western blot.Results β-catenin was expressed in cell membrane of normal brain tissue,while expressed in cytoplasm of brainstem and supratentorial gliomas.No significant difference was indicated between the three groups(P＞0.05) by semiquantitative analysis of β-catenin electrophoretic bands.Conclusions Although Wnt/β-catenin signal transduction pathway was involved in the tumorigenesis of gliomas,it was probably not a key factor which caused a worse prognosis of brainstem gliomas compared with supratentorial gliomas. Key words: Gliomas; Brainstem; β-catenin; Immunohistochemistry; Western blot
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