Expression and role of Hippo signaling pathway in non-small cell lung cancer

Abstract

Hippo signaling pathway plays an important role in the growth and regeneration of animal organs. Studies have shown that the misexpression of Hippo signaling pathway composed of yes-associated protein and trascriptional co-activator with PDZ-binding motif is involved in the development of non-small cell lung cancer (NSCLC) and has synergistic effect with mutant p53. In addition, its overexpression leads to drug resistance in lung cancer treatment and inhibition of its expression may benefit cancer patients. The expression and role of Hippo signaling pathway in NSCLC are described in detail, which is expected to provide a new direction for targeted therapy of lung cancer. Key words: Carcinoma, non-small-cell lung; Gene expression; Hippo signaling pathway; Targeted therapy