Expression and role of fibroblast growth factor receptor 4 in renal tissues from the children with renal disease

Abstract

Objective To investigate the expression and role of fibroblast growth factor receptor 4(FGFR 4)in renal tissues from the children with renal disease. Methods Paraffin-embedded renal biopsy tissue sections from 28 children with primary nephrotic syndrome(PNS), 18 children with acute glomerulonephritis(AGN), 20 children with Henoch-Schoenlein purpura nephritis(HSPN)and 22 children with isolated hematuria(IHU)were examined by immunohistochemical staining with anti- FGFR 4 monoclonal antibody.Normal renal tissues from 5 nephrectomized patients with nephroma were selected as control.Possible correlation between the expression of FGFR 4 and pathologic lesion score, clinical index of renal disease was analysed. Results The expression of FGFR 4 in proximal tubules, distal tubules and podocytes of children with renal disease are all significantly higher than that of the control group(P< 0.05).The expression of FGFR 4 in podocytes show negative correlation with pathologic lesion score of glomerulus and proteinuria(P<0.05).The expression of FGFR 4 in proximal tubules show positive correlation with pathologic lesion score of tubules and proteinuria(P<0.05).The expression of FGFR 4 in distal tubules show negative correlation with pathologic lesion score of tubules and proteinuria(P< 0.05). Conclusions The over expression of FGFR 4 take part in the onset and development of renal disease, but the role of FGFR 4 is different in different tissues: protective factor to podcytes and distal tubules, harmful factor to proximal tubules. Key words: fibroblast growth factor receptor 4; primary nephrotic syndrome; acute glomerulonephritis; Henoch-Schoenlein purpura nephritis; isolated hematuria