Abstract
BackgroundCyclooxygenase (cox) is the rate-limiting enzyme, which catalyzes the conversion of arachidonic acid into prostaglandins and contributes to the inflammatory process. Cyclooxygenase-2 (cox-2), which is one of the two isoforms, plays a role in tumor progression and carcinogenesis. p53 contributes to apoptosis, DNA renewal and cell cycle. Studies concerning the relationship of cox-2 and p53 expressions and carcinogenesis are available, but the association between cox-2 and p53 in Hodgkin lymphoma (HL) is not exactly known.In our study, we examined the association of cox-2 and p53 expression, with age, stage, histopathological subtype, and survival in HL. We also examined correlation between cox-2 and p53 expression.MethodsCox-2 and p53 expressions in Hodgkin-Reed Sternberg cells (HRS) were examined in 54 patients with HL depending on cox-2 expression, stained cases were classified as positive, and unstained cases as negative. Nuclear staining of HRS cells with p53 was evaluated as positive. The classifications of positivity were as follows: negative if<10%; (1+) if 10-25%; (2+) if 25-50%; (3+) if 50-75%, (4+) if >75%.ResultsCox-2 and p53 expressions were found in 49 (80%) and 29 (46%) patients, respectively. There were differences between histological subtypes according to cox-2 expression (p = 0.012). Mixed cellular (MC) and nodular sclerosing (NS) subtypes were seen most of the patients and cox-2 expression was evaluated mostly in the mixed cellular subtype.There were no statistically significant relationships between p53 and the histopathological subtypes; or between p53, cox-2 and the factors including stage, age and survival; or between p53 and cox-2 expression (p > 0.05).ConclusionConsidering the significant relationship between the cox-2 expression and the subtypes of HL, cox-2 expression is higher in MC and NS subtypes. However the difference between these two subtypes was not significant. This submission must be advocated by studies with large series
Highlights
Hodgkin lymphomas (HL) are malignancies derived from neoplastic Reed Sternberg (RS) cells which are found in the inflammatory media consist of plasma cells, eosinophils and histiocytes
It is reported in large series of epidemiologic studies that the risk of HL is lower in people using anti-inflammatory drugs, compared to the ones who do not use or who irregularly use nonsteroidal anti-inflammatory drugs (NSAIDs) [3]
The histological slides of all of the patients were reviewed by two blinded pathologists and categorized according to the WHO classification of hematological malignancies into nodular lymphocyte predominant (NLP), nodular sclerosing (NS), lymphocyte-rich (LR), mixed cellular (MC) and lymphocyte depleted (LD) type [1]
Summary
Hodgkin lymphomas (HL) are malignancies derived from neoplastic Reed Sternberg (RS) cells which are found in the inflammatory media consist of plasma cells, eosinophils and histiocytes. The RS and its variant Hodgkin (H) cells form 1-3% of the whole mass [1] It generates about 1% of the overall cancers and 30% of the lymphoid malignancies [1,2]. Various factors for the etiology have been widely studied, it is estimated that EBV infection contributes in some of the cases [2,3]. It is reported in large series of epidemiologic studies that the risk of HL is lower in people using anti-inflammatory drugs, compared to the ones who do not use or who irregularly use nonsteroidal anti-inflammatory drugs (NSAIDs) [3]. We examined correlation between cox-2 and p53 expression
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