Abstract
BackgroundEarly growth response proteins (EGRs), as a transcriptional regulatory family, are involved in the process of cell growth, differentiation, apoptosis, and even carcinogenesis. However, the role of EGRs in tumors, their expression levels, and their prognostic value remain unclear.MethodsUsing the Oncomine database, Kaplan–Meier Plotter, bcGenExMiner v4.2, cBioPortal, and other tools, the association between the survival data of breast carcinoma (BC) patients and transcriptional levels of four EGRs was investigated.ResultsAccording to the Oncomine database, in comparison to normal tissues, the expression level of EGR2/3 mRNA in BC tissues was decreased, but there was no difference in the expression level of EGR4 mRNA. On the basis of the Scarff-Bloom-Richardson (SBR) grading system, the downregulated expression level of EGR1/2/3 and upregulated expression level of EGR4 were correlated with an increased histological differentiation level, with significant differences (p < 0.05). Kaplan–Meier curves suggest that a reduction in EGR2/3 mRNA expression is related to recurrence-free survival (RFS) in BC patients. In addition, the mRNA expression level of EGR1/2/3 was related to metastatic relapse-free survival (MRFS) in BC patients with metastatic recurrence (p < 0.05).ConclusionEGR1/2/3 can be utilized as an important factor for evaluating prognosis and may be relevant to diagnosis. EGR4 may play a role in the occurrence and development of BC. The specific function and mechanism of EGRs in BC deserve further study.
Highlights
Breast carcinoma (BC) is currently the major cause of cancer-related deaths in women worldwide
The analysis showed that EGR1 and EGR2 were significantly downregulated in patients with breast carcinoma (BC) in 17 (35.4%) and 14 (53.8%) datasets, respectively, and EGR3 was significantly downregulated in four datasets
In the The Cancer Genome Atlas (TCGA) dataset, which contains 593 genetic samples from patients with BC, EGR1 expression was discovered in different invasive BCs and was significantly lower in BC (Table 1)
Summary
Breast carcinoma (BC) is currently the major cause of cancer-related deaths in women worldwide. Expression and prognostic analyses of early growth response proteins (EGRs) in human breast carcinoma based on database analysis. Using the Oncomine database, Kaplan–Meier Plotter, bcGenExMiner v4.2, cBioPortal, and other tools, the association between the survival data of breast carcinoma (BC) patients and transcriptional levels of four EGRs was investigated. Kaplan–Meier curves suggest that a reduction in EGR2/3 mRNA expression is related to recurrence-free survival (RFS) in BC patients. The mRNA expression level of EGR1/2/3 was related to metastatic relapse-free survival (MRFS) in BC patients with metastatic recurrence (p < 0.05). The specific function and mechanism of EGRs in BC deserve further study
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