Abstract
BackgroundSNF5 is a key protein in regulating cell proliferation and apoptosis in various cancers. However, the physiological roles of SNF5 in Endometrial carcinoma (EC), which is one of the most frequent malignancies of the female reproduction worldwide, remains unclear. This study aims to investigate the role of SNF5 and its correlation with clinicopathologic characteristics in EC.MethodsWe performed immunohistochemistry to detect the SNF5 expression in 46 endometrial carcinomas and 20 normal endometrium (non-EC) specimens, as well as analyzed the correlations between SNF5 expression and clinicopathologic features of patients using a statistics software (GraphPad Prism V6.0). Western blotting had been used to confirm the protein level of SNF5 in endometrial tissues. In addition, we evaluated the correlations between SNF5 and p21 in EC.ResultsThe positive immunostaining rate for SNF5 in EC and non-EC specimens were 65% (30/46) and 25% (5/20) respectively, and the expression of SNF5 was dramatically increased in EC compared with the normal endometrium (P < 0.01). The overexpression of SNF5 was associated with the PR levels, but not with age, FIGO stage, grade, lymphatic metastasis, myometrial invasion or ER status. Knockdown of SNF5 inhibits the expression of p21.ConclusionsOur results indicate that SNF5 plays an important role of promoting oncogenesis in EC. These findings open up the possibility for various novel and effective combination therapies targeting SNF5 in the EC.
Highlights
SNF5 is a key protein in regulating cell proliferation and apoptosis in various cancers
Sun et al BMC Women's Health (2019) 19:16 promoter of p21 gene to modulate its transcriptional activities, promoting cell growth in tumors [10]. These findings demonstrated that SNF5 and p21 may play tumor-progressive roles in a subset of atypical cancers [11, 12], which has become a very prevalent theoretical understanding
We evaluated the potential role of SNF5 in the progression of Endometrial carcinoma (EC) by measuring the expression levels of SNF5 in EC and normal endometrium tissues
Summary
SNF5 is a key protein in regulating cell proliferation and apoptosis in various cancers. The physiological roles of SNF5 in Endometrial carcinoma (EC), which is one of the most frequent malignancies of the female reproduction worldwide, remains unclear. Endometrial carcinoma (EC) is one of the most common gynecological malignancy in the world [1], whose incidence has been steadily increasing for decades in most countries. In China, EC has become the second most common cancer of the female reproductive system [2, 3], with an estimated 63.4 thousand new cases in 2015 [4]. As estrogen-dependent endometrioid carcinomas, Type I usually shows the positive expression of estrogen and progesterone receptors and is highly differentiated and less aggressive. Recent studies show that SNF5 can bind to the
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