Abstract
Anion channels and transporters in the gastrointestinal epithelium play essential roles in fluid secretion and absorption and participate in regulating the pH and ionic composition of the gut luminal contents. Diarrheas produced by bacterial enterotoxins such as cholera and rotavirus are associated, respectively, with activation of two kinds of Cl- channels, the cystic fibrosis transmembrane conductance regulator (CFTR) and Ca2+-activated Cl- channels (CaCCs). Although the roles and mechanisms of CFTR are relatively well understood, CaCCs have remained enigmatic partly because their molecular identity has remained in question.
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