Expression and importance of relaxin in vaginal wall tissues from women with pelvic organ prolapse and with/without stress urinary incontinence

Ilias Liapis,Matrona Frangou-Plemenou,Konstantinos Panoulis,Panagiotis Bakas,Aggelos Liapis,Charalampos Karachalios,Irene Labrinoudaki

doi:10.15761/cogrm.1000320

Ilias Liapis, Matrona Frangou-Plemenou + Show 5 more

Open Access

https://doi.org/10.15761/cogrm.1000320

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Abstract

Expression and importance of relaxin in vaginal wall tissues from women with pelvic organ prolapse and with/without stress urinary incontinence

Highlights

Pelvic organ prolapse is a stressful situation for women, which increases with age and depends on many factors, especially pregnancy and childbirth trauma
There are statistically significant differences regarding the intensity of relaxin expression between women with pelvic organ prolapse plus stress urinary incontinence and continent women with or without pelvic organ prolapse, as well as between women with prolapse plus incontinence and controls (P
Possible future interventions based on relaxin expression may aid in the non-surgical management of pelvic organ prolapse and stress urinary incontinence

Summary

Introduction

Pelvic organ prolapse is a stressful situation for women, which increases with age and depends on many factors, especially pregnancy and childbirth trauma. This condition becomes unbearable when combined with stress urinary incontinence, making women functionally disabled and downgrading their quality of life. These situations coexist at a rate of more than 50% of cases [1]. Pelvic support is based on functionality of extracellular matrix (ECM) in the connective tissue and is a mixture of long chain proteins, including collagen, elastin, and proteoglycans. The aim of this study was to assess the presence of relaxin in uterine supporting tissues from patients with pelvic organ prolapse and stress urinary continence

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