Abstract
Our results demonstrate the first findings of expression and function of the purinergic P2X 7 receptor (P2X 7R) in rat C6 glioma cells. P2X 7R mRNA and protein were present in unstimulated C6 cells and were up-regulated by cell exposure to the P2X 7R agonist, 2′,3′-(benzoyl-4-benzoyl)-ATP (BzATP). Activation of P2X 7R in C6 in response to BzATP led to increased mobilization of intracellular calcium [Ca 2+]i and formation of large pores. Chronic exposure of C6 cells to BzATP enhanced the expression of pro-inflammatory factors including MCP-1, IL-8 and VEGF. In a scratch-wound migration assay, the P2X 7R was shown to regulate cell mobility. The overall results suggest that P2X 7R activation in C6 is linked with increased pro-inflammatory factors and tumor cell migration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
