Abstract
Background. The homeostatic chemokine, CXCL13 (BLC, BCA-1), helps direct the recirculation of mature, resting B cells, which express its receptor, CXCR5. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. Objective. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin's lymphoma (AIDS-NHL). Methods. Serum CXCL13 levels were measured by ELISA in 46 subjects who developed AIDS-NHL in the Multicenter AIDS Cohort Study and in controls. The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDS-NHL cell lines. Results. Serum CXCL13 levels were significantly elevated in the AIDS-NHL group compared to controls. All primary AIDS-NHL specimens showed CXCR5 expression and most also showed CXCL13 expression. AIDS-NHL cell lines expressed CXCR5 and showed chemotaxis towards CXCL13. Conclusions. CXCL13/CXCR5 are expressed in AIDS-NHL and could potentially be involved in its biology. CXCL13 may have potential as a biomarker for AIDS-NHL.
Highlights
HIV infection is associated with a greatly increased risk of non-Hodgkin’s B cell lymphoma (NHL) [1,2,3]
We examined CXCL13 levels in AIDS-NHL subjects, using serum obtained at a mean time of 8.2 months prior to diagnosis
CXCL13 levels correlated with soluble CD44std (sCD44) levels in the AIDSNHL group (R = 0.31, P = .04), but not in the AIDS control group (R = 0.07; P = .7, data not shown); we previously showed that sCD44 levels are elevated prior to AIDS-NHL development [40]
Summary
HIV infection is associated with a greatly increased risk of non-Hodgkin’s B cell lymphoma (NHL) [1,2,3]. Levels of B cell-stimulatory cytokines, such as IL-6, are known to be elevated during HIV infection and are further elevated in those HIV(+) persons who go on to develop NHL [1, 6,7,8]. It has been shown that cytokines probably play an important role in the biology of AIDS-NHL, little work has been done on chemokines, cytokines that are most known for their ability to direct chemotaxis of immune cells [9]. CXCL13/CXCR5 are expressed, and may play a role, in some non-AIDS-associated B cell tumors. To determine if CXCL13/CXCR5 are associated with AIDS-related non-Hodgkin’s lymphoma (AIDS-NHL). The expression or function of CXCL13 and CXCR5 was examined on primary AIDS-NHL specimens or AIDSNHL cell lines. CXCL13 may have potential as a biomarker for AIDS-NHL
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