Abstract
Phospholipase A 2 (PLA 2) appears to play a fundamental role in cell injury in the central nervous system. We have investigated PLA 2 expression in the astrocytoma cell line 1231N1, and found that GIVA, GIVB, GIVC and GVI PLA 2 messages are expressed. PLA 2 activity is increased by inflammatory/injury stimuli such as interleukin-1β and lipopolysaccharide in these cells but with very different time courses. The arachidonic acid liberated is converted to prostaglandin E 2, possibly by cyclooxygenase-2, which is induced by inflammatory stimuli. This cell system emerges as a model to study injury/inflammation-related activation of the new PLA 2 forms GIVB and GIVC.
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