Abstract
Density and distribution of Ia antigen in the small intestine of C57bl/6 mice showed substantial differences, depending on the environment in which they were reared and maintained. Isolator-reared mice expressed low levels of epithelial Ia antigen in comparison to mice reared in a conventional environment. Oral administration of 10 micrograms of cholera toxin had no effect on the level of epithelial Ia expression. We conclude, therefore, that the mechanism whereby cholera toxin is able to potentiate mucosal responses to fed antigens is not related to changes in the level of epithelial Ia expression.
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