Expression and correlation of vitamin D and MMP-9 in chronic obstructive pulmonary disease

Abstract

Objective To detect the levels of 25-hydroxyvitamin D [25-(OH)D] and matrix metalloproteinase-9 (MMP-9) in COPD and to analyze the correlations of these indices.Methods Thirty-eight patients with acute exacerbations of COPD (AECOPD group),40 outpatients with stable COPD (stable COPD group) and 30 healthy subjects(control group) in the Third Hospital of Changsha were enrolled in our study from Jan.2012 to Mar.2012.Serum levels of 25-(OH)D and MMP-9 were measured in all subjects by the ELISA and compared among three groups.Correlations between 25-(OH)D and MMP-9 were analyzed in stable COPD group and AECOPD group.Results ①The levels of 25-(OH)D in AECOPD group and stable COPD group were significantly lower than those in control group (F =86.63,P ＜0.01).The level of 25-(OH)D in AECOPD group was significantly lower than that in stable COPD group (F =86.63,P ＜0.05).The levels of MMP-9 in AECOPD group and stable COPD group were significantly higher than those in control group (F =436.02,P ＜ 0.01).The level of MMP-9 in AECOPD group was significantly higher than that in stable COPD group (F =436.02,P ＜0.01).② Both in stable COPD group and AECOPD group,the 25-(OH)D levels were negatively correlated with the MMP-9 levels respectively (r =-0.638,P ＜0.01.r =-0.579,P ＜0.01,respectively).Conclusions Vitamin D in COPD showed lower expression,while higher expression of MMP-9.Vitamin D may affect the expression of MMP-9 in COPD. Key words: Chronic obstructive pulmonary disease; Vitamin D; Matrix metalloproteinase-9