Expression and correlation of ABCG2 and V-ATPase in NSCLC

Abstract

：Objective To investigatethe expressions of ABCG2 and V-ATPase in NSCLC and their expression rates in pathologicalclassification, TNM stages and pathological grades and the expression correlation betweenABCG2 and V-ATPase. Methods Expressions of ABCG2 and V-ATPase were accessed with EnVinsionimmunohistochemistry in tumor samples from 92 NSCLC patients. The corresponding data wasanalyzed statistically. Results Expressions of ABCG2 and V -ATPase were found both in thelung adenocarcinoma and lung squamous cell cancer, and the difference between these twokinds of tumors was significant (P =0.003,0.000). ABCG2 expression was significantlydifferent among TNM stages of lung adenocarcinoma (P=0.004) as well as among pathologicalgrades of lung adenocarcinoma (P =0.028) and squamous cell carcinoma (P =0.000), while nosignificant difference was found among TNM stages of squamous cell lung carcinoma. Thelevel of V-ATPase expression was associated with TNM stages of lung adenocarcinoma (P=0.026) and pathological grades of lung squamous cell carcinoma (P =0.002), however, amongTNM stages of lung squamous cell carcinoma and pathological grades of lung adenocarcinoma,the difference was not significant. Additionally, the significant correlation was foundbetween expression of ABCG2 and V-ATPase in all samples, adenocarcinoma and squamous cellcarcinoma (P<0.001). Conclusion The significant correlation is found between expressionof ABCG2 and V-ATPase, which indicate that they may co-work to participate in themechanism of anticancer drug resistance.