Expression and clinical significances of TGF-β1 and MMP-2 in papillary thyroid carcinoma with multiple foci

Abstract

Objective To study the expression and clinical significance of TGF-β1 and MMP-2 in mulitifocal papillary thyroid carcinoma (PTC).Methods Immunohistochemical S-P method was used to investigate the expression of TGF-β1 and MMP-2 in 47 cases of mulitifocal PTC and adjacent tissues.The expression of TGF-β1 and MMP-2 and the risk factors were analyzed between solitary PTC and multifocal PTC group.Results There were significant difference between mulitifocal thyroid cancer tissues,single focal PTCs and the adjacent tissue (P<0.05).Overexpressions of TGF-β1 and MMP-2 in mulitifocal PTCs were related to the degree of the infiltration,lymph node metastasis and tumor recurrence(P<0.05).The expression of TGF-β1 was correlated positively with MMP-2 (r＝0.920,P＝0.000).There was significant difference in expressions of TGF-β1 and MMP-2 between mulitifocal and single focal PTCs in lymph node metastasis and tumor recurrence groups (P<0.05).Conclusions The high expressions of TGF-β1 and MMP-2 in mulitifocal PTCs relate to the development,invasion,metastasis and recurrence.TGF-β1 and MMP-2 might be considered as biologic behavior indicators of mulitifocal PTC.