Abstract
Objective To investigate the expression of thioredoxin-1 in pancreatic cancer tissues and corresponding para-neoplastic tissues and explore its clinical significance. Methods The thiore-doxin-1 mRNA and protein expression levels in 30 cases of pancreatic cancer and corresponding para-neoplastic tissues were detected by RT-PCR and western blotting, respectively. Results The thiore-doxin-1 mRNA was over-expressed in the pancreatic cancer tissues (RI=0.80±0.08) compared with the para-neoplastic tissues (RI=0.39±0.15) by RT-PCR. The results of western blotting showed that the expression of thioredoxin-1 protein in pancreatic cancer tissues (PrI=0.81±0.10) were higher than that in corresponding para-neoplastic tissues (PrI=0.30±0.11). There was statistical significance (P 0.05). There were significant differences between Trx-1 expression in Ⅰ, Ⅱ and Ⅲ, Ⅳ stage cancerous tissues. Conclusion Thioredoxin-1 plays a key role in the growth of the pancreatic cancer. It may benefit the tumor survival and progress in hypoxia and oxidative stress. Key words: Pancreatic neoplasm; Thioredoxin
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