Expression and clinical significance of SSH1 in gastrointestinal stromal tumors

Abstract

Objective: To investigate the correlations between the expression of the slingshot-1(SSH1) and the general clinicopathological factors in gastrointestinal stromal tumor (GIST) patients. Methods: Immunohistochemical staining was used to detect the expression of SSH1 protein in 96 gastrointestinal stromal tumors, and the correlations between expression level of SSH1 and general clinicopathological factors were analyzed. Results: Totally, there were 96 cases of GIST patients (49 males and 47 males), with a mean age of (55.80±12.33) years. The tumors were located in different organs: 62 cases (64.6%) in the stomach, 29 cases (30.2%) in the intestine, and 5 cases (5.2%) in other organs, with a mean tumor size of (5.11±3.73) cm. The low risk group contained 57 cases (59.4%), 18 cases (18.8%) in middle risk group and 21 cases (21.9%) in high risk group. The pathological examination showed that the positive expression rate of CD117, CD34, DOG-1, Ki-67, SMA, S-100 and Desmin was 85.4%, 84.4%, 86.5%, 90.6%, 10.4%, 3.1% and 2.1%, respectively. In 96 cases of GIST, 37 cases (38.5%) had high expression of SSH1, and SSH1 expression level was correlated with the tumor invasion depth, risk classification, tumor mitotic figure count, CD34(+) (P<0.05). Conclusions: SSH1 plays an important role in the development of GIST. High expression of SSH1 is closely related to the invasion depth, risk classification and tumor mitosis of GIST.