Abstract
Objective:The current work aims to analyze the Nanog expression in tissue of several cancer types,explore its significance in the formation and development of tumor,and demonstrate its relationship with cancer stem cells.Methods:Nanog was detected via real-time PCR in 78 non-small-cell lung cancer(NSCLC ) tissue samples and 10 tissue samples adjacent to lung cance,39 gastric adenocarcinoma tissue samples and 10 tissue samples adjacent to gastric adenocarcinoma,and 35 of esophageal squamous cell carcinoma tissue samples and 10 tissue samples adjacent to esophageal carcinoma.Results:The Nanog expression was significantly higher in NSCLC,gastric adenocarcinoma,and esophageal squamous cell carcinoma tissue,with significant difference in NSCLC and gastric adenocarcinoma(P 0.05 ).The Nanog expression was related with the clinical stage and tumor histological classification in NSCLC(P 0.05 ),with the clinical stage and age in gastric adenocarcinoma(P 0.05 ),and with the clinical stage and lymph-node metastasis in esophageal squamous cell carcinoma(P 0.05 ).Conclusion:The Nanog expression was related with clinical stage, lymph-node metastasis,and tumor histological classification,suggesting that it might be associated with the formation and development of adenocarcinoma.
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