Abstract
Colorectal cancer is one of the most common malignant tumors in the digestive tract, ranking 4th in the fatal cause of malignant tumors [1], and its incidence is increasing year by year.
Highlights
Colorectal cancer is one of the most common malignant tumors in the digestive tract, ranking 4th in the fatal cause of malignant tumors [1], and its incidence is increasing year by year
MiR-218 may act as a tumor suppressor gene involved in tumor development
Some miRNAs are involved in the mediation of tumor suppressor genes, while others play a role as oncogenes
Summary
Colorectal cancer is one of the most common malignant tumors in the digestive tract, ranking 4th in the fatal cause of malignant tumors [1], and its incidence is increasing year by year. It is of great significance to further study the pathogenesis of colorectal cancer and find a more effective treatment for it. Studies have found that MicroRNAs (miRNAs or miRs) play an important role in cell proliferation, differentiation, apoptosis, gene regulation and tumor occurrence and development. Some miRNAs are involved in the mediation of tumor suppressor genes, while others play a role as oncogenes. More and more studies have shown that miRNAs have the role of oncogenes or tumor suppressors, and it plays an important role in the process of cell growth, proliferation and apoptosis. The abnormal expression level of miRNAs is related to the occurrence and development of many tumors. The study of the relationship between miRNAs and tumor is of great significance for exploring the occurrence, development and treatment of tumors
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