Expression and clinical significance of MIP-1 alpha in serum of asthmatic patients

Abstract

Objective To investigate the levels of serum macrophage inflammatory protein-1α (MIP-1α), inflammatory factors and pulmonary function in patients with asthma, and the correlation between them. Methods Eighty patients with asthma were selected who were treated in our hospital from March 2015 to August 2016, and the data of 80 healthy adults were selected as control. The differences of serum MIP-1α, inflammatory factors, immunoglobulin and lung function were observed in two groups. The correlation between MIP-1α and inflammatory factors, lung function and immunoglobulin were analyzed. Results The levels of MIP-1α, interleukin (IL)-6, and tumor necrosis factor-α (TNF-α) in patients with asthma were significantly higher than those in control group (t=-207.04, -33.209, -55.132, P<0.01); The levels of forced vital capacity (FVC), the forced expiratory volume in one second (FEV1), FEV1/FVC, maximal mid expiratory flow (MMEF), and peak expiratory flow (PEF) in the asthma group were significantly lower than those in the control group (t=17.100, 39.154, 22.791, 25.391, 19.356, P<0.01). The IgG and IgM of asthma group were significantly lower than those of the control group (t=9.564, 7.528, P<0.01). The IgE level was significantly higher than that of the control group (t=-82.683, P<0.01). The level of MIP-1α was positively correlated with the levels of IL-6, TNF-α and IgE, and negatively correlated with FVC, FEV1, FEV1/FVC, MMEF, PEF, IgG and IgM in patients with asthma. Conclusions The level of serum MIP-1α in asthmatic patients is high, and is closely related to the inflammatory cytokines and lung function in patients with asthma. Key words: Asthma; Chemokine CCL3/ME; Cytokines/ME; Inflammation; Respiratory function tests