Abstract
Objective To explore the expression of Kruppel-like factor 4 (KLF4) and kinesin family member 20A(KIF20A) in gastric carcinoma and their clinical value. Methods Gastric carcinoma tissues and adjacent gastric tissues of 69 patients confirmed pathologically at Affiliated Hospital of Guangdong Medical University From May 2014 to February 2019 were collected. The expression of KLF4 and KIF20A proteins in gastric carcinoma tissues and adjacent gastric tissues was detected by immunohistochemistry. Results The positive expression rate of KLF4 in gastric carcinoma tissues was significantly lower than that of adjacent gastric tissues (43.48% vs. 78.26%, t=17.524, P<0.01). The positive expression of KLF4 was significantly related with the histology grade, TNM stage and lymph node metastasis of gastric carcinoma (respectively, t=4.261, 4.653, 6.104, P<0.05). The positive expression rate of KIF20A in gastric carcinoma tissues was significantly higher than that of non-cancerous adjacent gastric tissues (66.67% vs. 20.29%, t=30.195, P<0.01), and the positive expression of KIF20A was related with gastric carcinoma to TNM stage and lymph node metastasis (respectively, t=6.048, 4.246, P<0.05). Conclusion There was low expression of KLF4 and high expression of KIF20A in gastric carcinoma tissues. Both KLF4 and KIF20A may play important role in the occurrence and development of gastric carcinoma. Key words: Kruppel-like factor 4; Kinesin family member 20A; Immunohistochemical method; Gastric carcinoma
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